This lecture introduces the problem of Type 1 Diabetes, the challenges faced by patients, caregivers, and clinicians when trying to manage this complex condition. As an alternative to finding the elusive cure for T1D, researchers around the world are pursuing the concept of an Artificial Pancreas. We discuss the impact of Systems Thinking on revealing the Big Picture, finding the right problem to solve for an effective disease management system, and to enable new opportunities that will improve the quality of life for millions of patients around the world. The discussion concentrates on the analysis of stakeholders in the Operation phase of the product development life cycle as an illustration of the power of Systems Thinking to devise a system architecture that satisfies the needs of a greater group of stakeholders, and that displays high-value emergent properties as a result of the functional interactions of its components.